[CAS NO. 1609465-88-4] (Rac)-PF-06250112

Name: (Rac)-PF-06250112
Brand: Arctom Scientific
SKU: HY-117900A

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PRODUCTS SPECIFICATIONS [1609465-88-4]

Distributor

Catalog

HY-117900A

Brand

MCE

CAS

1609465-88-4

DESCRIPTION [1609465-88-4]

Overview

MDL	-
Molecular Weight	438.43
Molecular Formula	C22H20F2N6O2
SMILES	O=C(C1=C(N)N(C2CN(C#N)CCC2)N=C1C3=CC=C(OC4=CC=C(F)C=C4F)C=C3)N

For research use only. We do not sell to patients.

Summary

(Rac)-PF-0625011 is a racemate of PF-06250112. PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor and shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC ^[1] .

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 250 mg/mL ( 570.22 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2809 mL	11.4043 mL	22.8087 mL
5 mM	0.4562 mL	2.2809 mL	4.5617 mL
10 mM	0.2281 mL	1.1404 mL	2.2809 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% Saline

Solubility: ≥ 2.08 mg/mL (4.74 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.74 mM); Clear solution

* All of the co-solvents are available by MedChemExpress (MCE).

References

[1] Rankin AL, et al. Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis. J Immunol. 2013 Nov 1;191(9):4540-50.