[CAS NO. 106372-55-8] Aspartame acesulfame

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PRODUCTS SPECIFICATIONS [106372-55-8]

Catalog

HY-118347

Brand

MCE

CAS

106372-55-8

DESCRIPTION [106372-55-8]

Overview

MDL	-
Molecular Weight	457.45
Molecular Formula	C18H23N3O9S
SMILES	O=C1NS(OC(C)=C1)(=O)=O.O=C(O)C[C@H](N)C(N[C@@H](CC2=CC=CC=C2)C(OC)=O)=O

For research use only. We do not sell to patients.

Summary

Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%) ^[1] ^[2] .

In Vitro

Aspartame is composed of phenylalanine (an important role in neurotransmitter regulation), aspartic acid (an excitatory neurotransmitter in the central nervous system) and methanol ^[2] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Aspartame (4000 mg/kg bw/day; p.o.) shows no adverse effect in acute, subacute and chronic toxicity studies with aspartame, and its decomposition products, conducted in mice, rats, hamsters and dogs ^[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00609986	Medical University of South Carolina	Kidney Transplantation\|Diabetes\|Hyperglycemia	July 2007	Not Applicable
NCT03708939	Weizmann Institute of Science	Glucose Intolerance\|Glucose, Low Blood\|Glucose, High Blood	February 19, 2017	Not Applicable
NCT02999321	Purdue University\|Ajinomoto USA, INC.	Oral Glucose Tolerance	August 17, 2016	Not Applicable
NCT05654285	Hospital Infantil de Mexico Federico Gomez	Obesity\|Diabetes Mellitus, Type 2\|Metabolic Syndrome	February 8, 2016	Not Applicable
NCT02545712	Bispebjerg Hospital\|Rigshospitalet, Denmark	Excipient Exposure\|Neonatal\|Pediatric	January 2016
NCT00731510	Medical Expeditions Ltd\|Bangor University\|Science in Sport\|Plans Branch of Headquarters Army Recruiting and Training Division	Hypoxia	June 2008	Not Applicable
NCT01200940	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|National Institutes of Health Clinical Center (CC)	Healthy Volunteers	November 4, 2010	Phase 1\|Phase 2
NCT01115088	Pennington Biomedical Research Center	Obesity\|Type 2 Diabetes	January 2006	Not Applicable
NCT02520258	Rockefeller University	Glucose Metabolism Disorder	August 2015	Not Applicable
NCT03954418	University of Aarhus	Pregnancy Related\|Diabetes\|IUGR	June 1, 2019	Not Applicable
NCT04567108	Brigham and Women´s Hospital\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Body Weight	April 22, 2021	Not Applicable
NCT02934321	University of Florida	Satiety in Healthy Volunteers	September 18, 2017	Not Applicable
NCT02459535	German Institute of Human Nutrition\|Ludwig-Maximilians - University of Munich	Pre-diabetes\|Diabetes	March 2015	Not Applicable
NCT01799096	University of Hull	Obesity	September 2006	Not Applicable
NCT01103921	University of California, Davis\|National Heart, Lung, and Blood Institute (NHLBI)	Metabolic Syndrome\|Insulin Resistance\|Dyslipidemia	October 2008	Not Applicable
NCT05967741	University of California, Davis	Platelet Aggregation, Spontaneous\|Vascular Thrombosis	July 20, 2023	Not Applicable
NCT02548767	University of California, Davis\|Touro University, California\|University of Southern California\|USDA, Western Human Nutrition Research Center\|National Heart, Lung, and Blood Institute (NHLBI)	Chronic Disease of Cardiovascular System\|Type 2 Diabetes\|Obesity	February 2016	Not Applicable

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.