[CAS NO. 5352-53-4] BPH-1358

Name: BPH-1358
Brand: Arctom Scientific
SKU: HY-118946

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PRODUCTS SPECIFICATIONS [5352-53-4]

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Catalog

HY-118946

Brand

MCE

CAS

5352-53-4

DESCRIPTION [5352-53-4]

Overview

MDL	-
Molecular Weight	601.53
Molecular Formula	C32H30Cl2N6O2
SMILES	O=C(C1=CC=C(C2=CC=C(C(NC3=CC=CC(C4=NCCN4)=C3)=O)C=C2)C=C1)NC5=CC=CC(C6=NCCN6)=C5.[H]Cl.[H]Cl

For research use only. We do not sell to patients.

Summary

BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC ₅₀ s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL) ^[1] ^[2] .

IC50 & Target

IC50: 1.8 μM (human bisphosphonate farnesyl diphosphate synthase) ^[1] ; 100 nM (undecaprenyl diphosphate synthase) ^[2]

In Vitro

BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC ₅₀ of 110 nM. BPH-1358 against E. coli and S. aureus with EC ₅₀ of 300 nM and 290 nM, respectively ^[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain) ^[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 6.25 mg/mL ( 10.39 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6624 mL	8.3121 mL	16.6243 mL
5 mM	0.3325 mL	1.6624 mL	3.3249 mL
10 mM	0.1662 mL	0.8312 mL	1.6624 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 0.62 mg/mL (1.03 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% Corn Oil

Solubility: ≥ 0.62 mg/mL (1.03 mM); Clear solution

* All of the co-solvents are available by MedChemExpress (MCE).