[CAS NO. 801985-13-7] BPH-1358 free base

Name: BPH-1358 free base
Brand: Arctom Scientific
SKU: HY-118946A

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PRODUCTS SPECIFICATIONS [801985-13-7]

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Catalog

HY-118946A

Brand

MCE

CAS

801985-13-7

DESCRIPTION [801985-13-7]

Overview

MDL	-
Molecular Weight	528.60
Molecular Formula	C32H28N6O2
SMILES	O=C(C1=CC=C(C2=CC=C(C(NC3=CC=CC(C4=NCCN4)=C3)=O)C=C2)C=C1)NC5=CC=CC(C6=NCCN6)=C5

For research use only. We do not sell to patients.

Summary

BPH-1358 free base (NSC50460 free base) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC ₅₀ s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL) ^[1] ^[2] .

IC50 & Target

IC50: 1.8 μM (human bisphosphonate farnesyl diphosphate synthase) ^[1] ; 100 nM (undecaprenyl diphosphate synthase) ^[2]

In Vitro

BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC ₅₀ of 110 nM. BPH-1358 against E. coli and S. aureus with EC ₅₀ of 300 nM and 290 nM, respectively ^[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain) ^[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.