[CAS NO. 60668-24-8] Alafosfalin
PRODUCTS SPECIFICATIONS [60668-24-8]
DESCRIPTION [60668-24-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 196.14 |
| Molecular Formula | C5H13N2O4P |
| SMILES | OP(O)([C@@H](NC([C@@H](N)C)=O)C)=O |
Summary
Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties [1] .
IC50 & Target
|
β-lactam |
In Vitro
Alafosfalin is highly active against Escherichia coli and moderately active against Serratia , Klebsiella , Enterobacter , and Citrobacter , but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus , Pseudomonas , and Acinetobacter [1] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t 1/2 ) of approximately 20 minutes [2] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Pairs of male SpragueDawley rats (250 to 350 g) [2] |
| Dosage: | 20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis) |
| Administration: | Administrated by s.c. |
| Result: | Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 250 mg/mL ( 1274.60 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.0984 mL | 25.4920 mL | 50.9840 mL |
| 5 mM | 1.0197 mL | 5.0984 mL | 10.1968 mL |
| 10 mM | 0.5098 mL | 2.5492 mL | 5.0984 mL |
References
- [1] H B Maruyama, et al. Alafosfalin, a New Inhibitor of Cell Wall Biosynthesis: In Vitro Activity Against Urinary Isolates in Japan and Potentiation With Beta-Lactams. Antimicrob Agents Chemother. 1979 Oct;16(4):444-51.
- [2] J G Allen, et al. Phosphonopeptides as Antibacterial Agents: Metabolism and Pharmacokinetics of Alafosfalin in Animals and Humans. Antimicrob Agents Chemother. 1979 Sep;16(3):306-13.
