[CAS NO. 1207258-55-6] NVS-CRF38
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PRODUCTS SPECIFICATIONS [1207258-55-6]
Catalog
HY-12339
Brand
MCE
CAS
1207258-55-6
DESCRIPTION [1207258-55-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 351.40 |
| Molecular Formula | C19H21N5O2 |
| SMILES | COC1=CC(C)=C(C2=C(C)OC3=C(N4N=C(C)N=C4C)C(C)=NN32)C=C1 |
For research use only. We do not sell to patients.
Summary
NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility. IC50 value: Target: CRF1 antagonist
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Stringer RA, et al. Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist. Xenobiotica. 2014 Apr 3.
- [2] Stringer RA, et al. 1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metab Dispos. 2014 Jul;42(7):1117-24.
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