[CAS NO. 2989453-29-2] Mps1-IN-3hydrochloride
PRODUCTS SPECIFICATIONS [2989453-29-2]
DESCRIPTION [2989453-29-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 574.09 |
| Molecular Formula | C26H32ClN7O4S |
| SMILES | OC1CCN(C2=CC=C(NC3=NC(NC4=CC=CC=C4S(=O)(C(C)C)=O)=C5N=CNC5=N3)C(OC)=C2)CC1.[H]Cl |
1 Publications Citing Use of MCE
Summary
IC50 & Target
IC 50 : 50 nM (Mps1) [1]
In Vitro
Mps1-IN-3 hydrochloride (0.3-10 μM) inhibits the marker of mitotic cells cyclin B in a dose-dependent manner
[1]
.
Mps1-IN-3 hydrochloride (2 μM) causes a dose-dependent escape from a checkpoint-mediated mitotic arrest
[1]
.
Mps1-IN-3 hydrochloride (1-15 μM) inhibits the proliferation of U251 glioblastoma cells with an IC
50
value of ~5 µM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Mps1-IN-3 hydrochloride (2 mg/kg; IV, twice a week, for 3 weeks) effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft models [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 20 mg/mL ( 34.84 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7419 mL | 8.7094 mL | 17.4189 mL |
| 5 mM | 0.3484 mL | 1.7419 mL | 3.4838 mL |
| 10 mM | 0.1742 mL | 0.8709 mL | 1.7419 mL |