[CAS NO. ] RI(dl)-2TFA

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PRODUCTS SPECIFICATIONS

Catalog

HY-126972A

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	435.59
Molecular Formula	C19H17N3.(1.3)C2HF3O2
SMILES	CCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.OC(C(F)(F)F)=O.[1.3]

For research use only. We do not sell to patients.

Summary

RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC ₅₀ of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells ( IC ₅₀ of 3.0 μM) ^[1] .

IC50 & Target

IC50: 11.1 μM (RAD51-mediated D-loop formation) ^[1]

In Vitro

RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA) ^[1] .
RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes when challenged with high concentrations of salt ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

[1] Wei Lv, et al. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 May 26;59(10):4511-25.