2’3’-c-di-AM(PS)2(Rp,Rp)enantiomerammoniumsalt
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 724.60 |
| Molecular Formula | C20H30N12O10P2S2 |
| SMILES | O[C@@H]1[C@H](O[P@@]2(S)=O)[C@@H](CO[P@@](O[C@H]([C@@H]3O)[C@H](N4C=NC5=C4N=CN=C5N)O[C@@H]3CO2)(S)=O)O[C@H]1N6C=NC7=C6N=CN=C7N.N.N |
Summary
ADU-S100 enantiomer ammonium salt (MIW815 enantiomer ammonium salt) is the less active enantiomer of ADU-S100. ADU-S100 is an activator of stimulator of interferon genes (STING) [1] .
In Vitro
STING is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides, resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines. The direct activation of the STING pathway might be an effective therapeutic strategy to promote broad tumor-initiated T cell priming against tumor antigen repertoire [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL ( 69.00 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.3801 mL | 6.9004 mL | 13.8007 mL |
| 5 mM | 0.2760 mL | 1.3801 mL | 2.7601 mL |
| 10 mM | 0.1380 mL | 0.6900 mL | 1.3801 mL |
