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[CAS NO. ] ERRαLigand-LinkerConjugates1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-130499 |
| Brand: | MCE |
| CAS: | - |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 601.42 |
| Molecular Formula | C24H20F9N3O5 |
| SMILES | NCCNC(/C(C#N)=C/C1=CC(OC)=C(C=C1)OCC2=C(C(F)(F)F)C=C(C(F)(F)F)C=C2)=O.O=C(C(F)(F)F)O |
Summary
ERRα Ligand-Linker Conjugates 1 incorporates a ligand for estrogen-related receptor alpha (ERRα) , and a PROTAC linker, which recruit E3 ligases MDM2 . ERRα Ligand-Linker Conjugates 1 can be used in the synthesis of a series of PROTACs , such as PROTAC ERRalpha Degrader-1 (HY-128838). PROTAC ERRalpha Degrader-1 is an ERRα degrader [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 200 mg/mL ( 332.55 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6627 mL | 8.3137 mL | 16.6273 mL |
| 5 mM | 0.3325 mL | 1.6627 mL | 3.3255 mL |
| 10 mM | 0.1663 mL | 0.8314 mL | 1.6627 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 5 mg/mL (8.31 mM); Clear solution
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