[CAS NO. 1415246-54-6]  Boc-Val-Dil-Dap-OH

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PRODUCTS SPECIFICATIONS [1415246-54-6]

Distributor
Catalog
HY-130961
Brand
MCE
CAS
1415246-54-6

DESCRIPTION [1415246-54-6]

Overview

MDL-
Molecular Weight571.75
Molecular FormulaC29H53N3O8
SMILESCC([C@H](NC(OC(C)(C)C)=O)C(N([C@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@H](C(O)=O)C)OC)=O)OC)[C@H](CC)C)C)=O)C

For research use only. We do not sell to patients.

Summary

Boc-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1] .


IC50 & Target

Cleavable


In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 174.90 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7490 mL 8.7451 mL 17.4902 mL
5 mM 0.3498 mL 1.7490 mL 3.4980 mL
10 mM 0.1749 mL 0.8745 mL 1.7490 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution

* All of the co-solvents are available by MCE.