Mitochondrialrespiration-IN-1hydrobromide
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 607.34 |
| Molecular Formula | C26H26Br2NO2PS |
| SMILES | O=C(OCCC1=C(C)N=CS1)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[H]Br.[Br-] |
Summary
Mitochondrial respiration-IN-1 hydrobromide (compound 49) is a potent mitochondrial inhibitor ( IC 50 =8.8 mg/mL) extracted from patent US20110301180A1, compound 49. Mitochondrial respiration-IN-1 hydrobromide significantly reduces mitochondrial respiration in platelets [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 164.65 mM ; Need ultrasonic)
DMSO : 66.67 mg/mL ( 109.77 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6465 mL | 8.2326 mL | 16.4652 mL |
| 5 mM | 0.3293 mL | 1.6465 mL | 3.2930 mL |
| 10 mM | 0.1647 mL | 0.8233 mL | 1.6465 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 11.11 mg/mL (18.29 mM); Clear solution; Need ultrasonic
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2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 5 mg/mL (8.23 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 5 mg/mL (8.23 mM); Clear solution
