[CAS NO. 2803211-60-9] GRP-60367hydrochloride
PRODUCTS SPECIFICATIONS [2803211-60-9]
DESCRIPTION [2803211-60-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 389.92 |
| Molecular Formula | C21H28ClN3O2 |
| SMILES | CC1=C(OCCNC2CCN(C(C3=CC=NC=C3)=O)CC2)C=C(C)C=C1.[H]Cl |
Summary
GRP-60367 hydrochloride is a first-in-class small-molecule rabies virus ( RABV ) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 hydrochloride specifically targets the RABV G protein [1] .
IC50 & Target
RABV [1]
In Vitro
GRP-60367 (0.1 nM-1000 μM) confirms specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC 50 s ranging from 2 to 52 nM on different host cell lines [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | BEAS-2B, 293T, or Hep-2 cell lines |
| Concentration: | 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1000 μM |
| Incubation Time: | 48 hours |
| Result: | EC 50 s of 2 nM, 3 nM, and 52 nM for RABV-ΔG-nanoLuc virus in BEAS-2B, 293T, or Hep-2 cell lines, respectively. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 250 mg/mL ( 641.16 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5646 mL | 12.8231 mL | 25.6463 mL |
| 5 mM | 0.5129 mL | 2.5646 mL | 5.1293 mL |
| 10 mM | 0.2565 mL | 1.2823 mL | 2.5646 mL |