[CAS NO. 2925713-02-4] UZH1
PRODUCTS SPECIFICATIONS [2925713-02-4]
DESCRIPTION [2925713-02-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 558.71 |
| Molecular Formula | C32H42N6O3 |
| SMILES | O=C(NCC1(O)CN(C2=NC=NC(NCC3=CC=CC=C3)=C2)CCC1)C4=CC=C(CN5CCC(C)(C)CC5)C=C4O |
2 Publications Citing Use of MCE
Summary
UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC 50 of 280 nM. UZH1b (IC 50 =28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor activity. UZH1 also can be used as a chemical probe for studying METTL3 [1] .
In Vitro
UZH1a (2.5-160 µM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC
50
s of 11 µM, 67 µM, and 87 µM, respectively
[1]
.
UZH1b (2.5-160 µM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC
50
s of 78 µM, 79 µM, and 93 µM, respectively
[1]
.
UZH1a (2.5-100 µM; 16 h) reduces m6A methylation level in mRNA from cells in a dose-dependent manner (IC
50
=4.6 µM), while UZH1b is less active at concentrations up to 100 µM in MOLM-13 cells
[1]
.
UZH1a (40 µM; 16 h) reduces m6A methylation level in mRNA from MOLM-13, HEK293T, and U2Os cells
[1]
.
UZH1a (20 µM; 16 h) increases apoptosis and leads to cell cycle arrest in MOLM-13 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 223.73 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7898 mL | 8.9492 mL | 17.8984 mL |
| 5 mM | 0.3580 mL | 1.7898 mL | 3.5797 mL |
| 10 mM | 0.1790 mL | 0.8949 mL | 1.7898 mL |