[CAS NO. 1007882-23-6] HCV-IN-30

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PRODUCTS SPECIFICATIONS [1007882-23-6]

Catalog

HY-136267

Brand

MCE

CAS

1007882-23-6

DESCRIPTION [1007882-23-6]

Overview

MDL	-
Molecular Weight	624.77
Molecular Formula	C36H44N6O4
SMILES	O=C(N1[C@H](C2=NC=C(C3=CC=C(C4=CC=C(C5=CN=C([C@H](CCC6)N6C(OC(C)(C)C)=O)N5)C=C4)C=C3)N2)CCC1)OC(C)(C)C

For research use only. We do not sell to patients.

Summary

HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC ₅₀ s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL ( 32.01 mM ; ultrasonic and adjust pH to 4 with HCl)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6006 mL	8.0029 mL	16.0059 mL
5 mM	0.3201 mL	1.6006 mL	3.2012 mL
10 mM	0.1601 mL	0.8003 mL	1.6006 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% Saline

Solubility: ≥ 2 mg/mL (3.20 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2 mg/mL (3.20 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% Corn Oil

Solubility: ≥ 2 mg/mL (3.20 mM); Clear solution

* All of the co-solvents are available by MedChemExpress (MCE).

References

[1] Belema M, et al. Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons. J Med Chem. 2014 Mar 13;57(5):1995-2012.