[CAS NO. 2769753-23-1] SK-3-91
PRODUCTS SPECIFICATIONS [2769753-23-1]
DESCRIPTION [2769753-23-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 887.40 |
| Molecular Formula | C42H47ClN10O8S |
| SMILES | O=C(N1C2C(NC(CC2)=O)=O)C3=C(NCC(NCCOCCN4CCN(C5=CC=C(NC6=NC(NC7=C(S(C(C)C)(=O)=O)C=CC=C7)=C(Cl)C=N6)C=C5)CC4)=O)C=CC=C3C1=O |
Summary
SK-3-91 is a multi-kinase degrader. SK-3-91 could collectively induce degradation of the largest number of unique kinases (>125 unique kinases) [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 200 mg/mL ( 225.38 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.1269 mL | 5.6344 mL | 11.2689 mL |
| 5 mM | 0.2254 mL | 1.1269 mL | 2.2538 mL |
| 10 mM | 0.1127 mL | 0.5634 mL | 1.1269 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 5 mg/mL (5.63 mM); Suspended solution; Need ultrasonic