[CAS NO. 1983984-01-5]  Avotaciclib trihydrochloride

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PRODUCTS SPECIFICATIONS [1983984-01-5]

Catalog
HY-137432A
Brand
MCE
CAS
1983984-01-5

DESCRIPTION [1983984-01-5]

Overview

MDL-
Molecular Weight390.66
Molecular FormulaC13H14Cl3N7O
SMILESOC1=CC=C(C2=NC(N)=NC=C2)N=C1C3=NC(N)=NC=C3.[H]Cl.[H]Cl.[H]Cl

For research use only. We do not sell to patients.

Summary

Avotaciclib (BEY1107) trihydrochloride is a potent and orally active inhibitor of cyclin dependent kinase 1 (CDK1) . Avotaciclib trihydrochloride can be used for the research of locally advanced or metastatic pancreatic cancer [1] .


IC50 & Target

CDK1


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT05093907 BeyondBio Inc.
Metastatic Colorectal Cancer
August 31, 2021 Phase 1|Phase 2
NCT03579836 BeyondBio Inc.
Locally Advanced or Metastatic Pancreatic Cancer
May 1, 2018 Phase 1|Phase 2
NCT05769660 BeyondBio Inc.
Glioblastoma Multiforme
November 29, 2022 Phase 1

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)


Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL ( 12.80 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5598 mL 12.7989 mL 25.5977 mL
5 mM 0.5120 mL 2.5598 mL 5.1195 mL
10 mM 0.2560 mL 1.2799 mL 2.5598 mL
* Please refer to the solubility information to select the appropriate solvent.