[CAS NO. 950913-56-1]  EFdA-TP

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PRODUCTS SPECIFICATIONS [950913-56-1]

Catalog
HY-138561
Brand
MCE
CAS
950913-56-1

DESCRIPTION [950913-56-1]

Overview

MDL-
Molecular Weight533.19
Molecular FormulaC12H15FN5O12P3
SMILESO=[P](O[P](O[P](O)(O)=O)(O)=O)(O)OC[C@]1(O[C@@](C[C@@H]1O)([H])N2C3=NC(F)=NC(N)=C3N=C2)C#C

For research use only. We do not sell to patients.

Summary

EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits HIV-1 RT with multiple mechanisms [1] .


IC50 & Target

HIV-1


In Vitro

EFdA-TP (0.05-10 μM; for 15 min) inhibits RT-catalyzed DNA synthesis as an ICT or DCT [1] .
EFdA-TP can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator. EFdA-TP can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis [1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.


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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.