[CAS NO. 2682112-08-7] Thalidomide-PEG3-COOH

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PRODUCTS SPECIFICATIONS [2682112-08-7]

Catalog

HY-138775

Brand

MCE

CAS

2682112-08-7

DESCRIPTION [2682112-08-7]

Overview

MDL	-
Molecular Weight	434.40
Molecular Formula	C20H22N2O9
SMILES	O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC=C(OCCOCCOCCC(O)=O)C=C31)=O

For research use only. We do not sell to patients.

Summary

Thalidomide-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology ^[1] .

IC50 & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 575.51 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3020 mL	11.5101 mL	23.0203 mL
5 mM	0.4604 mL	2.3020 mL	4.6041 mL
10 mM	0.2302 mL	1.1510 mL	2.3020 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

* All of the co-solvents are available by MCE.