[CAS NO. ] Thalidomide-Piperazine-PEG1-NH2diTFA

Name: Thalidomide-Piperazine-PEG1-NH2diTFA
Brand: Arctom Scientific
SKU: HY-138789A

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PRODUCTS SPECIFICATIONS

Distributor

Catalog

HY-138789A

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	657.52
Molecular Formula	C25H29F6N5O9
SMILES	OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(N4CCN(CCOCCN)CC4)=C3)=O

For research use only. We do not sell to patients.

Summary

Thalidomide-Piperazine-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology ^[1] .

IC50 & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 152.09 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5209 mL	7.6043 mL	15.2087 mL
5 mM	0.3042 mL	1.5209 mL	3.0417 mL
10 mM	0.1521 mL	0.7604 mL	1.5209 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (3.80 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.80 mM); Clear solution

* All of the co-solvents are available by MCE.