[CAS NO. 2797619-81-7] FTO-IN-1TFA

Name: FTO-IN-1TFA
Brand: Arctom Scientific
SKU: HY-138843A

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PRODUCTS SPECIFICATIONS [2797619-81-7]

Distributor

Catalog

HY-138843A

Brand

MCE

CAS

2797619-81-7

DESCRIPTION [2797619-81-7]

Overview

MDL	-
Molecular Weight	505.27
Molecular Formula	C20H17Cl2F3N4O4
SMILES	O=C(NO)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)NN=C3C)C=C2Cl.OC(C(F)(F)F)=O

For research use only. We do not sell to patients.

Summary

FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC ₅₀ of <1 μM. FTO-IN-1 TFA can be used for the research of cancer ^[1] .

IC50 & Target

IC50: <1 μM (FTO) ^[1]

In Vitro

FTO-IN-1 TFA (50 μM) inhibits FTO enzyme activity by 62% in vitro ^[1] .
FTO-IN-1 TFA (50 μM) inhibits the viability of SCLC-21H, RH30 and KP3 cells, with IC ₅₀ s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 98.96 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9791 mL	9.8957 mL	19.7914 mL
5 mM	0.3958 mL	1.9791 mL	3.9583 mL
10 mM	0.1979 mL	0.9896 mL	1.9791 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Yang C, et, al. 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof. WO2018157843A1.