[CAS NO. ]  Aminooxy-PEG3-bromidehydrobromide

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PRODUCTS SPECIFICATIONS

Distributor
Catalog
HY-140396C
Brand
MCE
CAS
-

DESCRIPTION

Overview

MDL-
Molecular Weight353.05
Molecular FormulaC8H19Br2NO4
SMILESNOCCOCCOCCOCCBr.Br

For research use only. We do not sell to patients.

Summary

Aminooxy-PEG3-bromide hydrobromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] .


IC50 & Target

PEGs


In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Oil


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)


Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 708.11 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8325 mL 14.1623 mL 28.3246 mL
5 mM 0.5665 mL 2.8325 mL 5.6649 mL
10 mM 0.2832 mL 1.4162 mL 2.8325 mL
* Please refer to the solubility information to select the appropriate solvent.