INCB059872 dihydrochloride
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 459.45 |
| Molecular Formula | C23H36Cl2N2O3 |
| SMILES | OC(C1(CCC1)CN2CCC(COC)(CC2)CN[C@H]3[C@@](C4=CC=CC=C4)([H])C3)=O.[H]Cl.[H]Cl |
Summary
INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 ( LSD1 ) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia [1] .
IC50 & Target
|
KDM1/LSD1 |
In Vitro
INCB059872 (25 nM; 48 hours; 293T cells) dihydrochloride increases enhancer activity and gene expression
[1]
.
INCB059872 (25 nM; 24 hours; THP-1 cells) dihydrochloride makes THP-1 show a growth defect within one cell doubling time or approximately 3 days
[1]
.
INCB059872 (THP-1 cells) dihydrochloride regulates PRO-seq analysis identifies genes and enhancers
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | 293T cells |
| Concentration: | 250 nM |
| Incubation Time: | 48 hours |
| Result: | Increased enhancer activity and gene expression. |
In Vivo
INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 days; C57BL/6J mice) dihydrochloride makes single-cell RNA-seq revealing changes in bone marrow progenitor populations [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | C57BL/6J mice [1] |
| Dosage: | 10 mg/kg |
| Administration: | p.o.; 0, 4, or 6 days |
| Result: | Single-cell RNA-seq revealed changes in bone marrow progenitor populations. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 3.57 mg/mL ( 7.77 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1765 mL | 10.8826 mL | 21.7652 mL |
| 5 mM | 0.4353 mL | 2.1765 mL | 4.3530 mL |
| 10 mM | --- | --- | --- |
