[CAS NO. 1820874-51-8] MMV674850

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PRODUCTS SPECIFICATIONS [1820874-51-8]

Catalog

HY-141837

Brand

MCE

CAS

1820874-51-8

DESCRIPTION [1820874-51-8]

Overview

MDL	-
Molecular Weight	452.55
Molecular Formula	C23H20N2O4S2
SMILES	CS(C(C=C1)=CC=C1C(C=N2)=C(N2C=C3)C=C3C4=CC(S(C5CC5)(=O)=O)=CC=C4)(=O)=O

For research use only. We do not sell to patients.

Summary

MMV674850 is potent against asexual stage parasites at 2.7 and 4.5 nM and preferentially targets early-stage gametocytes (early-stage gametocyte: IC ₅₀ 4.5 ± 3.6 nM; late-stage gametocyte: IC ₅₀ 28.7 ± 0.2 nM).

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Niemand J, et al. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infect Dis. 2021 Oct 8;7(10):2904-2916.