[CAS NO. 2764748-88-9] Carboxylesterase-IN-2
PRODUCTS SPECIFICATIONS [2764748-88-9]
DESCRIPTION [2764748-88-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 272.33 |
| Molecular Formula | C13H12N4OS |
| SMILES | O=C1NN=C2C=CC(SC3=CC=C(C)C(C)=C3)=NN21 |
Summary
Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC 50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 183.60 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6720 mL | 18.3601 mL | 36.7202 mL |
| 5 mM | 0.7344 mL | 3.6720 mL | 7.3440 mL |
| 10 mM | 0.3672 mL | 1.8360 mL | 3.6720 mL |
