[CAS NO. 3031984-78-5] (S)-V-0219
PRODUCTS SPECIFICATIONS [3031984-78-5]
DESCRIPTION [3031984-78-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 410.43 |
| Molecular Formula | C20H25F3N4O2 |
| SMILES | FC(C1=CC=C(C2=NOC(CN3C[C@H](CN4CCOCC4)CCC3)=N2)C=C1)(F)F |
Summary
(S)-V-0219 is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor -1 ( GLP-1R ). (S)-V-0219 activates calcium fluxes in HEK cells stably expressing hGLP-1R. (S)-V-0219 ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice [1] .
IC50 & Target
GLP-1R [1]
In Vitro
(S)-V-0219 ((S)-9) (0.1 nM) potentiates calcium fluxes in HEK cells stably expressing hGLP-1R
[1]
.
(S)-V-0219 (0.1 nM) potentiates insulin secretion stimulated by GLP-1 in the stable human pancreatic cell line EndoC-βH1 under high glucose concentration
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
(S)-V-0219 ((S)-9) (0.04-0.2 mg/kg; i.p.) improves glucose handling after injection of 2 g/kg glucose in normal male Wistar rats
[1]
.
(S)-V-0219 (0. 4 mg/kg; i.g.) is orally active in fatty diabetic Zucker rats
[1]
.
(S)-V-0219 (0.1-5 μg/kg in 5 μL; i.c.v.) decreases feeding in 12-h fasted male Wistar rats
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
