MRTX-EX185formic
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 610.68 |
| Molecular Formula | C34H35FN6O4 |
| SMILES | OC1=CC(C2=C(F)C3=NC(OCC45CCCN4CCC5)=NC(N6C[C@@](N7)([H])CC[C@@]7([H])C6)=C3C=N2)=C8C(C#C)=CC=CC8=C1.O=CO |
Summary
MRTX-EX185 formic is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D) , with an IC 50 of 90 nM for KRAS(G12D). MRTX-EX185 formic also binds GDP-loaded HRAS [1] .
IC50 & Target
|
KRas G12D 90 nM (IC 50 ) |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 204.69 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6375 mL | 8.1876 mL | 16.3752 mL |
| 5 mM | 0.3275 mL | 1.6375 mL | 3.2750 mL |
| 10 mM | 0.1638 mL | 0.8188 mL | 1.6375 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.08 mg/mL (3.41 mM); Suspended solution; Need ultrasonic
