[CAS NO. 92562-88-4]  Lagociclovir

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PRODUCTS SPECIFICATIONS [92562-88-4]

Catalog
HY-14844
Brand
MCE
CAS
92562-88-4

DESCRIPTION [92562-88-4]

Overview

MDL-
Molecular Weight269.23
Molecular FormulaC10H12FN5O3
SMILESO=C(N=C(N)N1)C2=C1N([C@@H]3O[C@H](CO)[C@@H](F)C3)C=N2

For research use only. We do not sell to patients.

Summary

Lagociclovir (FLG) is a nucleoside analogue that inhibits wild-type hepatitis B virus ( HBV ) replication in a human hepatoma cell line permanently expressing HBV [1] .


IC50 & Target

HBV [1]


In Vitro

Lagociclovir (FLG) (6 days) shows inhibitory activity with IC 50 s of 8 ± 3.8, 9 ± 2.5, 13 ± 3.4 and 15 ± 6.8 μM against 3TC-R HBV , wt HBV , PMEA-R HBV and 3TC+PMEA-R HBV , respectively in transiently transfected Huh7 cells [1] .
Lagociclovir (0-100 μM; 6 days) inhibits the replication of wild-type and drug-resistant mutants of HBV in transiently transfected Huh7 cells [1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.


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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.