- Cart - 0 item(s)
- $0.00
Your shopping cart is empty!
- Chemistry
- Bioactive Molecules
- Anti-infection
- Apoptosis
- Autophagy
- Cell Cycle/DNA Damage
- Cytoskeleton
- Epigenetics
- GPCR/G Protein
- Immunology/Inflammation
- JAK/STAT Signaling
- MAPK/ERK Pathway
- Membrane Transporter/Ion Channel
- Metabolic Enzyme/Protease
- Neuronal Signaling
- NF-κB
- PI3K/Akt/mTOR
- PROTAC
- Protein Tyrosine Kinase/RTK
- Stem Cell/Wnt
- TGF-beta/Smad
- Vitamin D Related/Nuclear Receptor
- Others
- Methylation
- Cytoskeletal Signaling
- Natural Products
- Alkaloids
- Amino acid
- Anthraquinones
- Cerebrosides
- Chalcones
- Coumarins
- Diterpenoids
- Flavonoids
- Iridoids
- Lignans
- Lipids
- Miscellaneous
- Monoterpenoids
- Other terpenes
- Phenols
- Phenylpropanoids
- Quinones
- Saccharides
- Sesquiterpenoids
- Steroids
- Tetraterpenoids
- Thiophenes
- Triterpenoids
- Xanthones
- Polyphenols
- Stibene glucosides
- Oligose
- Anthocyanins
- Miscellaneous
- Chromones
- Terpenoids
- Indoles
- Procyanidins
- Aliphatics
- Botanical Cyclopeptides
- ADCs
- Antibodies
- Multiplex IHC
- Material Science
- Others
[CAS NO. 2971704-85-3] RXFP2 agonist 2
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-150186 |
| Brand: | MCE |
| CAS: | 2971704-85-3 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 787.37 |
| Molecular Formula | C29H19F9IN3O5 |
| SMILES | O=C(N1[C@H]2CN(CC1)C(COC3=CC=C(C=C3I)OC(F)(F)F)=O)C4=CC(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=CC=C4NC2=O |
Summary
RXFP2 agonist 2 is a selective and allosteric RXFP2 agonist with an EC 50 value of 0.38 µM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis [1] .
IC50 & Target
EC 50 : 0.38 µM (RXFP2) [1]
In Vitro
RXFP2 agonist 2 (Compound 6641) (1, 3, 5 µM; 14 days) induces osteoblast mineralization at 3 and 5 µM with no cytotoxicity in HCO cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay [1]
| Cell Line: | HCO cells |
| Concentration: | 0-100 µM |
| Incubation Time: | 14 days |
| Result: | Induced mineralization of primary human osteoblasts and is non-cytotoxic. |
In Vivo
RXFP2 agonist 2 (10 mg/kg; p.o.; 3 times per week for 8 weeks) promotes bone formation in female mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 8-week-old WT C57BL/6 J female mice [1] |
| Dosage: | 3 mg/kg for i.v.; 10 mg/kg for p.o. |
| Administration: | I.v. or p.o. |
| Result: | Exhibited a half-life of between 4-6.5 h depending on the route of administration, with no accumulation at 10 mg/kg, and oral bioavailability around 25-31%. |
| Animal Model: | 8-week-old WT C57BL/6 J female mice [1] |
| Dosage: | 10 mg/kg |
| Administration: | P.o.; 3 times per week for 8 weeks |
| Result: | Increased bone formation in mouse with significantly increased in Tb.N and Tb.Th, and increased BV/TV and decreased Tb.Sp. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.