SARS-CoV-2-IN-23 disodium
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 910.88 |
| Molecular Formula | C52H50Na2O8P2 |
| SMILES | CC(CCOP(OC1=C2C(C3C4=C(C2C3)C=C5C(C6C7=C(C5C6)C=CC=C7)=C4)=C(C8=C1C9C%10=CC(C%11CC%12C%13=C%11C=CC=C%13)=C%12C=C%10C8C9)OP(OCCC(C)C)(O[Na])=O)(O[Na])=O)C |
Summary
SARS-CoV-2-IN-23 disodium is a two-armed diphosphate ester and medium length molecular tweezers. SARS-CoV-2-IN-23 disodium exhibits antiviral activity with IC 50 s of 8.2 μM and 2.6 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-23 disodium induces liposomal membrane disruption with an EC 50 value of 4.4 μM [1] .
IC50 & Target
IC50: 4.4 μM (viral liposome, SARS-CoV-2) [1]
In Vitro
SARS-CoV-2-IN-23 (CP002) disodium inhibits SARS-CoV-2 (IC
50
=2.6 μM) with a low cytotoxicity (Caco2 cells, CC
50
=97 μM)
[1]
.
SARS-CoV-2-IN-23 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC
50
value of 8.2 μM
[1]
.
SARS-CoV-2-IN-23 disodium suppresses varies enveloped viruses activity with IC
50
s of 38.4 μM (influenza A virus, IAV), 2.8 μM (measles virus, MeV), 1.1 μM (herpes simplex viruses, HSV-1), and human immunodeficiency virus type 1 (HIV-1), respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃) |
| Concentration: | 0, 0.23, 0.93, 3.75, 15 μM |
| Incubation Time: | 2 hours; determined infection rates on day 2 |
| Result: | Inhibited SARS-CoV-2 infection activity to Caco2 cells. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.