SARS-CoV-2-IN-28 disodium
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 966.98 |
| Molecular Formula | C56H58Na2O8P2 |
| SMILES | CCCCCCCOP(OC(C1=C2C3C4=CC(C5CC6C7=C5C=CC=C7)=C6C=C4C1C3)=C(C8C9=C(C%10C8)C=C%11C(C%12C%13=C(C%11C%12)C=CC=C%13)=C9)C%10=C2OP(OCCCCCCC)(O[Na])=O)(O[Na])=O |
Summary
SARS-CoV-2-IN-28 disodium is a two-armed diphosphate ester with C7 alkyl and molecular tweezers with extended length. SARS-CoV-2-IN-28 disodium exhibits antiviral activity with IC 50 s of 0.4 μM and 1.0 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-28 disodium induces liposomal membrane disruption with an EC 50 value of 4.4 μM [1] .
IC50 & Target
IC50: 4.4 μM (viral liposome, SARS-CoV-2) [1]
In Vitro
SARS-CoV-2-IN-28 (CP020) disodium inhibits SARS-CoV-2 (IC
50
=1.0 μM) with few cytotoxicity (Caco2 cells, CC
50
=213.1 μM)
[1]
.
SARS-CoV-2-IN-28 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC
50
value of 0.4 μM
[1]
.
SARS-CoV-2-IN-28 disodium suppresses varies enveloped viruses activity with IC
50
s of 7.1 μM (respiratory syncytial virus, RSV), 24.5 μM (influenza A virus, IAV), 4.0 μM (measles virus, MeV), 1.6 μM (herpes simplex viruses, HSV-1), respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃) |
| Concentration: | 0, 0.23, 0.93, 3.75, 15 μM |
| Incubation Time: | 2 hours; determined infection rates on day 2 |
| Result: | Inhibited SARS-CoV-2 infection activity to Caco2 cells. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.