[CAS NO. ]  SARS-CoV-2-IN-29 disodium

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PRODUCTS SPECIFICATIONS

Catalog
HY-151276A
Brand
MCE
CAS
-

DESCRIPTION

Overview

MDL-
Molecular Weight978.91
Molecular FormulaC58H46Na2O8P2
SMILESCC(C=C1)=CC=C1COP(OC(C2=C3C4C5=CC(C6CC7C8=C6C=CC=C8)=C7C=C5C2C4)=C(C9C%10=C(C%11C9)C=C%12C(C%13C%14=C(C%12C%13)C=CC=C%14)=C%10)C%11=C3OP(OCC%15=CC=C(C=C%15)C)(O[Na])=O)(O[Na])=O

For research use only. We do not sell to patients.

Summary

SARS-CoV-2-IN-29 disodium is a two-armed diphosphate ester with benzene system and molecular tweezers. SARS-CoV-2-IN-29 disodium exhibits antiviral activity with IC 50 s of 1.5 μM and 1.6 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-29 disodium induces liposomal membrane disruption with an EC 50 value of 3.0 μM [1] .


IC50 & Target

IC50: 3.0 μM (viral liposome, SARS-CoV-2) [1]


In Vitro

SARS-CoV-2-IN-29 (CP024) disodium inhibits SARS-CoV-2 (IC 50 =1.6 μM) with low cytotoxicity (Caco2 cells, CC 50 =77.4 μM) [1] .
SARS-CoV-2-IN-29 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC 50 value of 1.5 μM [1] .
SARS-CoV-2-IN-29 disodium suppresses varies enveloped viruses activity with IC 50 s of 2.1 μM (influenza A virus, IAV), 2.1 μM (measles virus, MeV), 1.8 μM (herpes simplex viruses, HSV-1), respectively [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay [1]

Cell Line: Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
Concentration: 0, 0.23, 0.93, 3.75, 15 μM
Incubation Time: 2 hours; determined infection rates on day 2
Result: Inhibited SARS-CoV-2 infection activity to Caco2 cells.

Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.