[CAS NO. 2827065-28-9] Antitumor agent-74
PRODUCTS SPECIFICATIONS [2827065-28-9]
DESCRIPTION [2827065-28-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 438.50 |
| Molecular Formula | C26H23FN6 |
| SMILES | CN1CCN(C2=CC=C3N=C(C4=CC=C(F)C=C4)C(C5=NC6=CC=CC=C6N5)=NC3=C2)CC1 |
Summary
Antitumor agent-74 (compound 13da) is a quinoxalines derivative, an antitumor agent. Antitumor agent-74 exhibits more potent efficacy on tumor inhibition, mixed with regioisomer Antitumor agent-75 (HY-151295, compound 14 da) (mriBIQ 13da/14da). mriBIQ 13da/14da attests cell cycle at S phase, inhibits DNA synthesis, and induces mithochondrial apoptosis [1] .
In Vitro
Antitumor agent-74 (compound 13da) shows lower cytotoxicity (IC
50
s=56.7-86.3 μM) against cancer cells than mriBIQ 13da/14da (IC
50
s=2.8-34.0 μM)
[1]
.
mriBIQ 13da/14da shows high selectivity on A549 cells over normal embryonic lung cells (Wi38), with selectivity index of 12 (IC
50
of Wi38/A549)
[1]
.
mriBIQ 13da/14da (1-100 μM; 48 h) inhibtis A549 cells proliferation and decreases the rate of cell division in A549 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | M-HeLa, MCF-7, HuTu-80, PANC-1, A549, PC3, T98G, Wi38 cells |
| Concentration: | 0-100 μM |
| Incubation Time: | 48 hours |
| Result: | Showed low cytotoxicity and inhibited cancer cells with IC 50 s of 58.7, 67.3, 75.6, 86.3, 65.6, 63.2, 68.7, and 56.7 μM, respectively. |
Cell Proliferation Assay [1]
| Cell Line: | A549 |
| Concentration: | mriBIQ 13da/14da: 1, 5, 25, 50, 100 μM |
| Incubation Time: | 48 hours |
| Result: | Decreased the rate of cell division, associated with induction of apoptosis in A549 cells. |
Cell Cycle Analysis [1]
| Cell Line: | A549 |
| Concentration: | mriBIQ 13da/14da: 1, 2.5, 5 μM |
| Incubation Time: | 12 hours |
| Result: | Increased the number of cells in the S-phase at 1, 2.5, and 5 μM of 49.0%, 66.3%, and 68.0%, respectively. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.