[CAS NO. 3033645-28-9] Chitin synthase inhibitor 5
PRODUCTS SPECIFICATIONS [3033645-28-9]
DESCRIPTION [3033645-28-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 500.34 |
| Molecular Formula | C23H22BrN3O5 |
| SMILES | COC1=CC2=C(NC(OC23CCN(CC3)C(/C=C/C(NC4=CC=C(C=C4)Br)=O)=O)=O)C=C1 |
Summary
Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC 50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans , A. flavus , A. fumigatus and C. neoformans . Chitin synthase inhibitor 5 can be used for the research of fungal [1] .
IC50 & Target
IC50: 0.14 mM (chitin synthase) [1]
In Vitro
Chitin synthase inhibitor 5 (300 μg/mL; 1 h) inhibits chitin synthase with an IC
50
value of 0.14 mM
[1]
.
Chitin synthase inhibitor 5 (1-512 μg/mL; 24 h) shows antifungal activities to
C. albicans
,
A. flavus
,
A. fumigatus
and
C. neoformans
with MIC values of 26.67, 32, 64 and 64 μg/mL, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.