[CAS NO. 3033645-29-0] Chitin synthase inhibitor 6
PRODUCTS SPECIFICATIONS [3033645-29-0]
DESCRIPTION [3033645-29-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 451.47 |
| Molecular Formula | C24H25N3O6 |
| SMILES | O=C(NC1=CC=C(OC)C=C1)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O |
Summary
In Vitro
Chitin synthase inhibitor 6 (compound 9b; 300 μg/mL) inhibits chitin synthase (CHS) activity with an inhibition percentage (IP) value of 82%
[1]
.
Chitin synthase inhibitor 6 (1-512 μg/mL) has antifungal activity against four strains with minimum inhibitory concentration (MIC) values of 64, 64, 128, and 256 μg/mL for
C. albicans
,
A. flavus
,
A. fumigatus
, and
C. neoformans
, respectively
[1]
.
Chitin synthase inhibitor 6 (0-256 μg/mL (50 μL), 24 h) shows strong synergistic effect against
A. fumigatus
when combinated with
Fluconazole
(HY-10219). Chitin synthase inhibitor 6 and fluconazole combination against
C. neoformans
(FIC = 0.625) and additive effect against
C. albicans
(FIC = 1.10).
A. fumigatus
(FIC = 1.125)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
