[CAS NO. 3033645-30-3] Chitin synthase inhibitor 7

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PRODUCTS SPECIFICATIONS [3033645-30-3]

Catalog

HY-151417

Brand

MCE

CAS

3033645-30-3

DESCRIPTION [3033645-30-3]

Overview

MDL	-
Molecular Weight	435.47
Molecular Formula	C24H25N3O5
SMILES	O=C(NC1=CC=C(C)C=C1)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O

For research use only. We do not sell to patients.

Summary

Chitin synthase inhibitor 7 (compound 9c) is a potent chitin synthase (CHS) inhibitor with an IC ₅₀ value of 0.37 mM. Chitin synthase inhibitor 7 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 7 can be used in the research of fungi infection ^[1] .

In Vitro

Chitin synthase inhibitor 7 (compound 9c; 300 μg/mL) inhibits chitin synthase (CHS) activity with an inhibition percentage (IP) value of nearly 70% ^[1] .
Chitin synthase inhibitor 7 (1-512 μg/mL) has antifungal activity against four strains with minimum inhibitory concentration (MIC) values of 128, 256, 256, and 256 μg/mL for C. albicans , A. flavus , A. fumigatus , and C. neoformans , respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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References

[1] Xu Y, et, al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723.