[CAS NO. 3033645-31-4] Chitin synthase inhibitor 8
PRODUCTS SPECIFICATIONS [3033645-31-4]
DESCRIPTION [3033645-31-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 421.45 |
| Molecular Formula | C23H23N3O5 |
| SMILES | O=C(NC1=CC=CC=C1)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O |
Summary
IC50 & Target
Chitin synthase [1]
In Vitro
Chitin synthase inhibitor 8 (compound 9d, 300 μg/mL) inhibits chitin synthase (CHS) by 69%
[1]
.
Chitin synthase inhibitor 8 (0.0625-0.25 μM, 24 h) shows antifungal activities
[1]
.
Chitin synthase inhibitor 8 (32 μg/mL, 24 h) shows strong synergistic effect against
A. fumigatus
when combinated with
Fluconazole
(HY-10219)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | C. albicans , A. flavus , A. fumigatus , C. neoformans |
| Concentration: | 1-512 μg/mL |
| Incubation Time: | 24 h |
| Result: | Inhibited four fungi with IC 50 value of 64, 53.33, 15.08, 64 μg/mL respectively. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.