[CAS NO. 2725075-01-2] Chitin synthase inhibitor 10
PRODUCTS SPECIFICATIONS [2725075-01-2]
DESCRIPTION [2725075-01-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 609.26 |
| Molecular Formula | C24H23Br2N3O6 |
| SMILES | O=C(NC1=C(Br)C=C(OC)C=C1Br)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O |
Summary
Chitin synthase inhibitor 10 is a chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 10 shows excellent CHS inhibitory activity with an IC 50 value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans . Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs) [1] .
IC50 & Target
In Vitro
Chitin synthase inhibitor 10 (compound 9o) (300 ug/mL) has good inhibitory activity against chitin synthase (CHS) with with an IC
50
value of 0.11 mM
[1]
.
Chitin synthase inhibitor 10 has antifungal activity for
C. albicans
,
A. flavus
,
A. fumigatus
and
C. neoformans
with MIC values of 64 μg/mL, 256 μg/mL, 128 μg/mL and 64 μg/mL, respectively
[1]
.
Chitin synthase inhibitor 10 is related to the disruption of cell wall architecture
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.