[CAS NO. 2725075-04-5] Chitin synthase inhibitor 11
PRODUCTS SPECIFICATIONS [2725075-04-5]
DESCRIPTION [2725075-04-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 496.47 |
| Molecular Formula | C24H24N4O8 |
| SMILES | O=C(NC1=CC=C([N+]([O-])=O)C=C1OC)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O |
Summary
Chitin synthase inhibitor 11 is a chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 11 shows excellent CHS inhibitory activity with an IC 50 value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs) [1] .
IC50 & Target
In Vitro
Chitin synthase inhibitor 11 (compound 9s) (300 ug/mL) has good inhibitory activity against chitin synthase (CHS) with with an IC
50
value of 0.10 mM
[1]
.
Chitin synthase inhibitor 11 has antifungal activity for
C. albicans
,
A. flavus
,
A. fumigatus
and
C. neoformans
with MIC values of 128μg/mL, 42.67 μg/mL, 64 μg/mL and 64 μg/mL, respectively
[1]
.
Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro and has additive or synergistic effects combined with fluconazole
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.