[CAS NO. 2725075-05-6] Chitin synthase inhibitor 12
PRODUCTS SPECIFICATIONS [2725075-05-6]
DESCRIPTION [2725075-05-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 473.88 |
| Molecular Formula | C23H21ClFN3O5 |
| SMILES | O=C(NC1=CC=C(F)C(Cl)=C1)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O |
Summary
Chitin synthase inhibitor 12 is a chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 12 shows excellent CHS inhibitory activity with an IC 50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans . Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs) [1] .
IC50 & Target
In Vitro
Chitin synthase inhibitor 12 (compound 9t) (300 ug/mL) has good inhibitory activity against chitin synthase (CHS) with with an IC
50
value of 0.16 mM
[1]
.
Chitin synthase inhibitor 12 has antifungal activity for
C. albicans
,
A. flavus
,
A. fumigatus
and
C. neoformans
with MIC values of 64 μg/mL, 16 μg/mL, 64 μg/mL and 64 μg/mL, respectively
[1]
.
Chitin synthase inhibitor 12 has broad-spectrum antifungal activity in vitro and has additive or synergistic effects combined with fluconazole
[1]
.
Chitin synthase inhibitor 12 is related to the disruption of cell wall architecture
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.