[CAS NO. ] Antifungal agent 40

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PRODUCTS SPECIFICATIONS

Catalog

HY-151437

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	490.29
Molecular Formula	C22H20Cl2N4Se
SMILES	ClC1=CC=C(C([Se]C(C2=CC=C(Cl)C=C2)CN3C=CN=C3)CN4C=CN=C4)C=C1

For research use only. We do not sell to patients.

Summary

Antifungal agent 40 is an antifungal agent which extends into the narrow hydrophobic pocket II of C.alb. CYP51 . Antifungal agent 40 has an inhibitory effect on lanosterol 14α-demethylase (CYP51). Antifungal agent 40 inhibits biofilm formation ^[1] .

IC50 & Target

CYP51 ^[1]

In Vitro

Antifungal agent 40 (compound A03, 0.25-128 μg/mL) inhibits fungal activity with MIC values of 1-64 μg/mL ^[1] .
Antifungal agent 40 (1-8 μg/mL, 16 h) inhibits lanosterol 14α-demethylase (CYP51) of C.alb (GC-MS analysis) ^[1] .
Antifungal agent 40 (0.5 μg/mL, 1.5-24 h) displays antibiofilm activity against FCZ-Resistant C.alb ^[1] .
Antifungal agent 40 (0-10 μM respectively) shows cytotoxicity against HL-60, MDA-MB-231 and PC-3 cells with IC ₅₀ values of 5.18, 3.25, 0.98 μM respectively ^[1] .
Antifungal agent 40 (2-32 μg/mL, 3 h) displays high hemolysis rate in rabbit erythrocyte ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Hang Xu, et al. Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51. Eur J Med Chem. 2022 Aug 28;243:114707.