[CAS NO. ]  Antifungal agent 42

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PRODUCTS SPECIFICATIONS

Catalog
HY-151440
Brand
MCE
CAS
-

DESCRIPTION

Overview

MDL-
Molecular Weight569.25
Molecular FormulaC22H20Cl2N4Se2
SMILESClC1=CC=C(C([Se][Se]C(C2=CC=C(Cl)C=C2)CN3C=CN=C3)CN4C=CN=C4)C=C1

For research use only. We do not sell to patients.

Summary

Antifungal agent 42 is an antifungal agent. Antifungal agent 42 has an inhibitory effect on lanosterol 14α-demethylase (CYP51) of C.alb. . Antifungal agent 42 inhibits biofilm formation [1] .


IC50 & Target

CYP51 [1]


In Vitro

Antifungal agent 42 (compound B03, 0.25-128 μg/mL) inhibits fungal activity with MIC values of 1-64 μg/mL [1] .
Antifungal agent 42 (0.5 μg/mL, 1.5-24 h) displays antibiofilm activity against FCZ-Resistant C.alb [1] .
Antifungal agent 42 (0-20 μM approximately) shows cytotoxicity against HL-60, MDA-MB-231 and PC-3 cells with IC 50 values of 12.5, 5.5, 2.91 μM respectively [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.