[CAS NO. ] ZIKV-IN-4

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PRODUCTS SPECIFICATIONS

Catalog

HY-151447

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	511.65
Molecular Formula	C33H37NO4
SMILES	C=C(CC[C@]1([H])[C@@]/2(COC(C3=CC=CC=C3)C4=CC=CC=C4)C)[C@@H](/C=C/C5=CCOC5=O)[C@]1(C)CCC2=N/O

For research use only. We do not sell to patients.

Summary

ZIKV-IN-4 (compound 5b) is a low-cytotoxicity and acid-stable anti- ZIKV agent ( EC ₅₀ =3.49 μM). ZIKV-IN-4 effectively inhibits the activity of ZIKV NS5 MTase ^[1] .

IC50 & Target

EC50:3.49 μM (ZIKV) ^[1] .

In Vitro

ZIKV-IN-4 (0-200 μM; 96 h) shows low cytotoxicity ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay ^[1]

Cell Line:	Vero cells
Concentration:	0-200 μM
Incubation Time:	96 h
Result:	Exhibited low cytotoxicities with a CC ₅₀ value of more than 200 μM.

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References

[1] Qian W, et al. Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5. Eur J Med Chem. 2022 Aug 27;243:114710.