[CAS NO. 1802363-75-2]  Metallo-β-lactamase-IN-9

Metallo-β-lactamase-IN-9 (Compound 23) (10 and 50 mg/kg; s.c.; three times a day for 1 day) reduces bacterial burden in both the spleen and kidney in combination with Imipenem (HY-B1369A) in a Klebsiella pneumoniae MB9249 infection mice model ^[1] .
Mouse Pharmacokinetic Properties of Metallo-β-lactamase-IN-9 (Compound 23) ^{d [1]}

dose a (iv, mpk)	AUC (μM·h)	MRT (h)	V dss (L/kg)	Cl (mL/min/kg)
5 a	27.08	5.2	2.97	9.33

dose (sc, mg/kg)	AUC (μM·h)	C max (μM)	T max (h)
10 b	27.42	13.4	0.83
50 c	111.28	69.1	0.5

^a Formulation, 1.0 mg/mL 23 in 20% DMSO/60% PEG400/20% water (solution) with dose volume of 5 mL/kg.
^b Formulation, 1.0 mg/mL of 23 in 30% captisol (solution) with dose volume 10 mL/kg.
^c Formulation, 5.0 mg/mL of 23 in 30% captisol (solution) with dose volume of 10 mL/kg.
^d AUC, area under the curve; Cl, clearance; iv, intravenous, MRT, mean residence time; V _dss , volume of distribution at steady state.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.