[CAS NO. ] JB061

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS

Catalog

HY-152205

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	323.34
Molecular Formula	C19H17NO4
SMILES	OC(C1=CC=CC=C1O2)=C(/C(C)=N/CC3=CC=CC(OC)=C3)C2=O

For research use only. We do not sell to patients.

Summary

JB061 is a nonmuscle myosin inhibitor with IC ₅₀ s of 4.4 μM ( Cardiac muscle myosin ), 9.1 μM ( Skeletal muscle myosin ), and >100 μM ( Smooth muscle myosin II ), respectively. JB061 poorly decreases ATPase activity ( IC ₅₀ >200 μM). JB061 shows cytotoxicity against COS-7 cells with an IC ₅₀ value of 39 μM ^[1] .

IC50 & Target

Cardiac muscle myosin

4.4 μM (IC ₅₀ )

Skeletal muscle myosin

9.1 μM (IC ₅₀ )

Smooth muscle myosin II

>100 μM (IC ₅₀ )

In Vitro

JB061 (compound 6a) (40 μM; 24 h) inhibits cytokinesis in Cos-7 cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Smith JD, et al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008.