Reverse transcriptase-IN-4
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 343.45 |
| Molecular Formula | C17H21N5OS |
| SMILES | CC1=CC(C)=CC(C(C2=C(C(NC(SC(C)C)=N2)=O)C)N=[N+]=[N-])=C1 |
Summary
Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase ( NNRT ) inhibitor with an EC 50 value of 0.053 μM for wild-type HIV-1 and an EC 50 value of 0.26 μM for HIV-1 mutant E138K [1] .
In Vitro
Reverse transcriptase-IN-4 (compound F10) (0-10 μM) shows very weak inhibitory effects on all CYP enzymes, and the inhibitory activities of CYP1A2, CYP2D6, CYP3A4T and CYP3A4M exceeds 50 μM. No significant inhibition is observed for CYP2C9 and CYP2C19, with IC
50
values of 35.8 μM and 27.1 μM, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Reverse transcriptase-IN-4 (compound F10) (1.0 g/kg, p.o) is well tolerated in mice, has no acute toxicity and has a good in vivo safety profile
[1]
。
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.