[CAS NO. 791117-61-8] Physachenolide C
PRODUCTS SPECIFICATIONS [791117-61-8]
DESCRIPTION [791117-61-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 544.63 |
| Molecular Formula | C30H40O9 |
| SMILES | CC(C(OC1[C@]([C@@]2(CC[C@]3(C4C[C@@H]5[C@](O5)(CC=CC6=O)[C@]6(C4CC[C@@]32COC(C)=O)C)O)O)(C)O)=O)=C(C1)C |
Summary
In Vitro
Physachenolide C (0.01-10 μM, 48 h) inhibits Yale University Mouse Melanoma (YUMM) cell lines YUMM2.1 and YUMMER1.7 with the IC
50
values of 0.5159 μM and 1.8230 μM, respectively and results in a significant increase in early apoptotic cells, causing cells to stagnate in the G0-G1 phase
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Physachenolide C (20 mg/kg IT daily for 15 doses) significantly inhibits tumour growth and caused complete tumour regression in a mouse model of melanoma, with no significant toxic effects in mice. Also, tumours treated with Physachenolide C shows a significant increase in the percentage of TUNEL-positive cells (40%)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.