SARS-CoV-2 3CLpro-IN-9
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 473.56 |
| Molecular Formula | C25H35N3O6 |
| SMILES | COC1=CC=CC=C1[C@H]2C[C@@H]2COC(N[C@H](C(N[C@@H](C[C@H]3CCNC3=O)C=O)=O)CC(C)C)=O |
Summary
SARS-CoV-2 3CLpro-IN-9, an aldehyde, is a broad-spectrum cyclopropane-based inhibitor of coronavirus 3C-like proteases (3CL pro ). SARS-CoV-2 3CLpro-IN-9 inhibits SARS-CoV-2 , SARS-CoV-1 and MERS-CoV 3CL pro with IC 50 values of 140 nM, 350 nM, 120 nM, respectively. SARS-CoV-2 3CLpro-IN-9 inhibits SARS-CoV-2 replication with an IC 50 value of 11 nM [1] .
In Vitro
SARS-CoV-2 3CLpro-IN-9 (compound 11c) has a CC 50 of >100 μM in confluent cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.