Topoisomerase IIα-IN-7
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 497.80 |
| Molecular Formula | C22H23Cl3N4O3 |
| SMILES | O=C(NC1=C(OCC2=CC(C(NCCN)=O)=CC=C2)C=CC=C1)C3=C(Cl)C(Cl)=C(C)N3.Cl |
Summary
Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC 50 value of 7.7 µM and have stable metabolism. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells, among them, Topoisomerase IIα-IN-7 is most effective for leukemia cell lines with an IC 50 value of 0.19 µM [1] .
IC50 & Target
|
topoisomerase II alpha 7.7 μM (IC 50 ) |
In Vitro
Topoisomerase IIα-IN-7 (Compound 53b) (50 µM; 72 h) shows high cytotoxicity to cancer cell lines with IC
50
values of 130 nM and 140 nM for HepG2 and MCF-7 cancer cell lines, respectively
[1]
.
Topoisomerase IIα-IN-7 (50 µM; 72 h) has cytotoxicity to MCF-7 cancer cell line, HepG2 cancer cell line and human embryonic kidney derived HEK293 cells with IC
50
values of 0.15 µM, 0.13 µM and 2.1 µM respectively
[1]
.
Topoisomerase IIα-IN-7 (100 µM; 0, 15, 30, 60, 120 min) has metabolic stability and the half-life is more than 5 hours in the rat liver S9
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
