[CAS NO. 2925481-88-3] BAY-805
PRODUCTS SPECIFICATIONS [2925481-88-3]
DESCRIPTION [2925481-88-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 507.57 |
| Molecular Formula | C24H28F3N5O2S |
| SMILES | O=C([C@@H](CC(C)C)NC(C1(C(F)(F)F)CCCCC1)=O)NC2=NN=C(CC3=CC=C(C#N)C=C3)S2 |
Summary
BAY-805 is a chemical probe and selectively inhibits ubiquitin-specific protease USP21 . BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes [1] .
IC50 & Target
USP21 [1]
In Vitro
BAY-805 inhibits the activity of hUSP21 HTRF and hUSP21 Ub-Rhod with IC
50
values of 6 nM and 2 nM, respectively
[1]
.
BAY-805 (10 µM) induces the NF-κB activation with an EC
50
value of 17 nM
[1]
.
BAY-805 (10 µM and 50 µM) significantly inhibits the activity of USP21 and also shows weak influence on USP22 and USP10
[1]
.
BAY-805 (0.0001-1000000 nM) selectively inhibits the activity of USP21
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.